血栓素A_2(TXA_2)和前列环素(PGI_2)是体内二个生物活性很强的花生四烯酸(AA)代谢产物,目前认为二者在体内呈平衡状态,此平衡的失调可能与一些疾病的发生有关。一些资料表明,改变这一平衡,使向有利于PGI_2合成方向发展,对于某些疾病的防治具有积极的作用。因此,近年来人们对选择性血栓素合成酶抑制剂(TXSI)做了大量的工作,并取得一些成 Thromboxane A 2 (TXA 2) and prostacyclin (PGI 2) are two biologically active arachidonic acid (AA) metabolites in the body and are currently thought to be in equilibrium in the body. The imbalance of this balance may be related to some diseases The occurrence of. Some sources suggest that changing this balance will have a positive effect on PGI-2 synthesis and prevention and treatment of certain diseases. Therefore, in recent years, a great deal of work has been done on selective thromboxane synthase inhibitors (TXSIs)