目的探讨乳腺癌的位置与血液供应及其与术前介入化学药物治疗（下称化疗）疗效的关系。方法应用Ｓｅｌｄｉｎｇｅｒ技术对１５例Ⅲ期乳腺癌患者造影，并经乳腺癌癌灶供血动脉采用顺铂、阿霉素、丝裂霉素和５氟尿嘧啶（ＰＡＭＦ）进行灌注化疗。结果乳腺癌的肿瘤供血与部位有关：外侧病灶１１例主要由胸外侧动脉供血，内侧病灶４例主要由胸廓内动脉供血。乳腺癌采用ＰＡＭＦ进行介入化疗后，肿瘤及腋窝淋巴结明显缩小，根治术后１５例均获随访，随访时间２～６年，７例生存期达５年以上，仅２例于术后３年后复发，与同期Ⅲ期乳癌未作介入化疗者相比，复发率明显降低，差异有非常显著意义（Ｐ＜００１）。结论晚期乳腺癌如无化疗禁忌症，应考虑作术前介入化疗，以提高疗效。介入化疗时应仔细全面观察，确认其主要供血动脉是术前介入化疗成功的关键 Objective To investigate the relationship between the location and blood supply of breast cancer and its effect on preoperative interventional chemotherapy (hereinafter referred to as chemotherapy). Methods Seldinger technique was used to scan 15 patients with stage III breast cancer. The breast arteries of breast cancer were treated with cisplatin, adriamycin, mitomycin and 5-fluorouracil (PAMF). Results The tumor blood supply of breast cancer was related to the site: 11 cases of lateral lesion were mainly supplied by lateral thoracic artery, and 4 cases of medial lesion were mainly supplied by internal thoracic artery. After PAMF interventional chemotherapy for breast cancer, the tumor and axillary lymph nodes were significantly reduced. All 15 patients were followed up after radical resection. The follow-up time was 2 to 6 years. 7 patients survived for more than 5 years, and only 2 patients were postoperative 3 years later. The recurrence rate was significantly lower than that of patients with stage III breast cancer without intervention chemotherapy (P<001). Conclusion If there is no chemotherapy contraindication for advanced breast cancer, preoperative interventional chemotherapy should be considered to improve the efficacy. The interventional chemotherapy should be carefully and comprehensively observed to confirm that the main blood supply artery is the key to successful preoperative interventional chemotherapy