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背景:临床上肾移植后贫血发生率为30%~40%,是肾移植后心血管疾病和移植肾失功的重要危险因素,并且是患者死亡的独立预测指标。目的:分析肾移植后贫血发生的相关因素。方法:分析2000-01/2009-12解放军沈阳军区总医院肾移植826例患者资料,其中男541例,女285例,年龄17~71岁;尸体供肾805例,亲体活体供肾21例。根据移植后是否发生贫血将患者分成贫血组与非贫血组,记录可能引起移植后贫血的各项参数,分别用t检验和卡方检验进行单因素分析。结果与结论:826例肾移植患者中发生贫血225例,发生率为27.2%。女性和男性患者贫血发生率分别为23%和37%(P<0.05);年龄26~65岁,其中伴有高血压应用血管紧张素转化酶抑制剂或血管紧张素Ⅱ受体拮抗剂类降压药物者46例,伴有慢性糜烂性胃:炎或上消化道溃疡者16例,人存活率为85.3%,肾失功率为25.3%;非贫血组601例,占总例数的72.8%,其中男405例,女196例,年龄17~71岁,伴有高血压应用血管紧张素转化酶抑制剂或血管紧张素Ⅱ受体拮抗剂降压药物者35例,伴有慢性糜烂性胃炎或上消化道溃疡者14例,人存活率为92.1%,肾失功率为12.6%,与贫血组对比差异有显著性意义(P<0.05)。分析表明,性别、年龄、肾功能、消化道疾病史、药物因素等与肾移植后贫血的发生密切相关。
BACKGROUND: The clinical incidence of anemia after renal transplantation is 30% -40%. It is an important risk factor for cardiovascular diseases and renal allograft failure after kidney transplantation and is an independent predictor of patient mortality. Objective: To analyze the related factors of anemia after renal transplantation. Methods: The data of 826 renal transplant recipients from Shenyang Military Region General Hospital of PLA from January 2000 to December 2009 were analyzed, including 541 males and 285 females, aged 17-71 years. There were 805 donor corpses and 21 donor corpuscles. Patients were divided into anemia group and non-anemia group according to whether there was anemia after transplantation. The parameters that may cause post-transplantation anemia were recorded and analyzed by t-test and chi-square test respectively. RESULTS AND CONCLUSION: Anemia occurred in 225 of 826 renal transplant recipients, with a rate of 27.2%. The incidence of anemia in female and male patients was 23% and 37%, respectively (P <0.05). Aged 26-65 years old, with ACE inhibitors or angiotensin II receptor antagonists 46 patients with pressure medication, accompanied by chronic erosive stomach: inflammation or upper gastrointestinal ulcer in 16 cases, human survival rate was 85.3%, renal failure rate was 25.3%; non-anemia group 601 cases, accounting for 72.8% of the total number of cases, , Of which 405 were males and 196 were females, aged 17 to 71 years, with hypertension or angiotensin-converting enzyme inhibitor angiotensin Ⅱ receptor antagonist antihypertensive drugs in 35 patients with chronic erosive gastritis Or upper gastrointestinal ulcer in 14 cases, the survival rate of 92.1%, renal failure rate was 12.6%, with the difference between the anemia group was significant (P <0.05). Analysis showed that gender, age, renal function, gastrointestinal disease history, drug factors and anemia after renal transplantation is closely related to the occurrence.