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目的探讨纳洛酮试验在急性脑梗死溶栓治疗前的应用价值。方法１８例急性脑梗死患者溶栓治疗前进行纳洛酮试验，观察静脉溶栓前后神经功能变化，同时观察颅内出血的副作用。结果纳洛酮试验神经功能缺损评分减少８分的患者１３例（Ａ组），减少不足８分或评分增加的患者５例（Ｂ组）；Ａ组神经功能缺损评分治疗前２２７８±５００分，治疗后５２３±３２２分（Ｐ＜００１），而Ｂ组治疗前２２８０±４１５分，治疗后１８８０±７６９分（Ｐ＞００５）；Ａ组发生颅内出血１例，Ｂ组发生３例（Ｐ＜００１）。结论纳洛酮试验阳性患者溶栓治疗疗效好，颅内出血机率小。在溶栓治疗前纳洛酮试验可起到初步筛选病例的作用。
Objective To investigate the value of naloxone test before thrombolytic therapy in acute cerebral infarction. Methods 18 patients with acute cerebral infarction were treated with naloxone before thrombolysis. The changes of neurological function before and after intravenous thrombolysis were observed, and the side effects of intracranial hemorrhage were observed. Results In the naloxone group, 13 patients (group A) with a decrease of 8 points in neurological deficit scores, 5 patients (group B) less than 8 points or with an increase in score (group B), and 22.78 ± 5 00 points, 523 ± 3.22 points after treatment (P <001), while those in group B were 2280 ± 415 minutes before treatment and 1880 ± 769 minutes after treatment (P0.05 ⑤05); intracranial hemorrhage in group A occurred in 1 case, and in group B occurred in 3 cases (P <001). Conclusion Naloxone positive patients with thrombolytic therapy curative effect, a small chance of intracranial hemorrhage. Naloxone test before thrombolytic therapy can play a preliminary screening of cases.