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本文报道健康兔６只静注替考拉宁后的药物动力学。血药浓度用微生物法测定。单剂静注替考拉宁２０ｍｇ／ｋｇ后，体内药物转运过程符合二室开放模型。静注后即刻血药浓度为１４１．１１±４２．０３μｇ／ｍｌ，分布相半衰期为０．１０±０．０３小时，消除相半衰期为３．４８±０．６５小时。表现分布容积为０．１３±０．０３Ｌ／ｋｇ。药时曲线下面积为１７５．６１±１８．９８ｈ·μｇ／ｍｌ，总清除率为０．１１±０．０２Ｌ／（ｈ·ｋｇ）。
This article reports the pharmacokinetics of 6 rabbits after intravenous teicoplanin injection. Blood concentration was determined by microbiological method. A single intravenous teicoplanin 20mg / kg, in vivo drug transport process in line with two-compartment open model. Immediate intravenous plasma concentration of 141.11 ± 42.03μg / ml, distribution phase half-life of 0.10 ± 0.03 hours, elimination phase half-life of 3.48 ± 0.65 hours. Performance distribution volume of 0.13 ± 0.03L / kg. The area under the curve was 175.61 ± 18.98h · μg / ml and the total clearance rate was 0.11 ± 0.02L / (h · kg).