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以家兔凝血时间的延长作为分级定量的药理指标,测定了蝮蛇抗栓酶 iv 给药的药动学参数和 ig给药的生物利用度。按二室开放模型拟合的结果如下:t_(1/2α)=1.12h;t_(1/2β)=3.8h;k_(12)=0.039h~(-1);k_(21)=0.56h~(-1);k_(10)=0.21h~(-1);CL=0.021kg/kg·h;V_c=0.098kg/kg;V_p=0.0069kg/kg;V_(ss)=0.105kg/kg;F=10.9%。
Taking the prolongation of clotting time of rabbits as the pharmacological index for grading and quantification, the pharmacokinetic parameters and the bioavailability of ig administration were determined. The results of fitting the two-compartment open model are as follows: t 1 / 2α = 1.12h; t 1/2 1/2 = 3.8h; k 12 = 0.039h -1; k 21 = 0.56 h -1; k_ (10) = 0.21 h -1; CL = 0.021 kg / kg.h; V_c = 0.098 kg / kg; V_p = 0.0069 kg / kg; V ss = /kg;F=10.9%.