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ＩＬ１２ 是一种重要的抗肿瘤细胞因子，它主要有以下作用：激发ＮＫ／ＬＡＫ 细胞及Ｔ细胞的增殖，分化及向肿瘤部位趋化；诱导ＩＦＮγ的产生；促进巨噬细胞释放ＮＯ；抑制肿瘤血管形成等。应用ＩＬ１２ 进行抗肿瘤治疗可通过以下途径：直接给予ＩＬ１２ 蛋白；将克隆入ＩＬ１２ 基因的细胞注射至肿瘤生长部位；用含ＩＬ１２ 基因的病毒感染肿瘤细胞；直接将含ＩＬ１２ 基因的质粒注入体内。另外它尚可作为免疫佐剂增强ＡＰＣ细胞提呈肿瘤特异性抗原的能力。
IL-12 is an important anti-tumor cytokine, which mainly has the following effects: provoking the proliferation, differentiation and chemotaxis of NK/LAK cells and T cells; inducing the production of IFN-γ; promoting macrophage release NO; inhibition of tumor blood vessel formation. The use of IL-12 for anti-tumor therapy can be achieved by direct administration of IL-12 protein; injection of cells cloned into IL-12 into the site of tumor growth; infection of tumor cells with a virus containing IL-12; The IL-12 plasmid is injected into the body. In addition, it can be used as an immune adjuvant to enhance the ability of APC cells to present tumor-specific antigens.