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目的分析雷贝拉唑联合马来酸曲美布汀治疗胃食管反流病的疗效。方法将我院消化内科2008年9月—2011年9月的96例胃食管反流病患者,随机分为二组,每组各48例,观察组给予雷贝拉唑联合马来酸曲美布汀,对照组给予奥美拉唑联合多潘立酮。观察分析比较二组患者治疗前后临床症状发作频率、症状严重程度及疗效。结果治疗8周后二组患者临床发作频率及症状程度积分均较治疗前显著下降(P<0.01),且观察组积分明显低于对照组(P<0.01);观察组的总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论雷贝拉唑联合马来酸曲美布汀是一种安全、高效的治疗GERD的方法。
Objective To analyze the efficacy of rabeprazole and trimebutine maleate in the treatment of gastroesophageal reflux disease. Methods 96 cases of gastroesophageal reflux disease in our hospital from September 2008 to September 2011 were randomly divided into two groups, 48 cases in each group. The observation group was given rabeprazole in combination with trimebutine maleate Buding, control group given omeprazole combined domperidone. Observation and analysis of two groups of patients before and after treatment of clinical symptoms of seizure frequency, severity of symptoms and efficacy. Results After 8 weeks of treatment, the scores of clinical seizure frequency and symptom scores in both groups were significantly lower than those before treatment (P <0.01), and the scores in the observation group were significantly lower than those in the control group (P <0.01). The total effective rate in the observation group was significantly higher In the control group, the difference was statistically significant (P <0.05). Conclusion Rabeprazole combined with trimebutine maleate is a safe and effective method for the treatment of GERD.