核因子KB(nuclear factor KB,NF-KB)是一种重要的核转录因子,由一个复杂的体系组成。它不仅存在于B细胞,而且也存在于T细胞,非淋巴细胞,Hela细胞等多种细胞。目前发现它调节着100多种靶基因的表达,如细胞因子、化学趋化因子、生长因子、粘附分子。某些急性期反应蛋白以及参与免疫识别的受体和抗原递呈的蛋白质等,大多数均参与宿主的免疫和炎症反应。而近年来许多研究证实,氯胺酮影响着NF-KB调控下的非特异性免 Nuclear factor KB (NF-KB) is an important nuclear transcription factor, composed of a complex system. It exists not only in B cells, but also in T cells, non-lymphocytes, Hela cells and other cells. It is now found to regulate the expression of more than 100 target genes, such as cytokines, chemoattractants, growth factors, and adhesion molecules. Some acute phase reaction proteins, as well as proteins involved in immune recognition and antigen presentation, are mostly involved in host immune and inflammatory responses. In recent years, many studies confirm that ketamine affects the nonspecific immunity under NF-KB regulation