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目的:了解我院门诊苯二氮类药物(BDZ)的使用情况。方法:随机抽取华中科技大学同济医学院附属精神病医院2005年1月-12月1a中门诊西药处方6472张,对其中1824张含有苯二氮类药物的处方进行分析。并用限定日剂量(DDD)和药物利用指数(DUI)为指标分析其使用情况。结果:含有苯二氮类药物的处方占总处方的28.18%,出现率最高的为氯硝西泮,占43.04%;依次为阿普唑仑25.0%,地西泮16.67%,艾司唑仑9.70%,硝西泮5.04%,劳拉西泮0.55%。其中地西泮、硝西泮和劳拉西泮的DUI均略小于1;阿普唑仑、氯硝西泮和艾司唑仑的DUI略大于1。处方中用药时间超过4周的处方高达60.42%,其中超过12周的处方为8.33%,最高处方日数为150d。结论:该院医师对苯二氮类药品的滥用倾向不明显,但对苯二氮类药物使用存在着日处方数较高等方面问题。
Objective: To understand the use of benzodiazepines (BDZ) in our hospital. Methods: 6472 prescriptions of outpatient western medicine in January-December 2005 from psychiatric hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology were randomly selected and 1824 prescriptions containing benzodiazepines were analyzed. The use of DDD and DUI was analyzed. Results: The prescriptions containing benzodiazepines accounted for 28.18% of the total prescriptions, the highest incidence of clonazepam, accounting for 43.04%; followed by alprazolam 25.0%, diazepam 16.67%, eszolazole Lun 9.70%, nitrazepam 5.04%, lorazepam 0.55%. The DUI of diazepam, nitrazepam and lorazepam were slightly less than 1, while the DUI of alprazolam, clonazepam and estazolam was slightly larger than 1. Prescriptions over 60% of prescriptions over 4 weeks were prescribed, with 8.33% over 12 weeks and maximum prescription days of 150 days. CONCLUSION: The hospital physician’s abuse of benzodiazepines is not obvious, but there is a problem of higher daily prescription for the use of benzodiazepines.