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目的 :研究抗中性粒细胞浆抗体 (antineutrophil cytoplasmic antibody,ANCA)与肾小球肾炎的关系。方法 :采用间接免疫荧光法及酶联免疫吸附法 ,对 48例各种类型的肾小球肾炎作血抗中性粒细胞浆抗体定性及定量测定 ,同时进行临床、病理、实验室检查对照。结果 :(1)在 48例肾小球肾炎患者中有 12例 ANCA阳性 ;(2 ) ANCA阳性患者的临床表现不尽相同 ;(3)在 ANCA阳性患者的肾小球内大多有新月体形成 ,血管病变及间质炎症 ;(4)ANCA阳性患者血中 TNF均高于正常值 ,在肾小球内的不同部位均可发现粘附因子 VCAM- 1沉积。结论 :一些肾小球肾炎实际上就是血管炎的一类 ,无论是病理变化 ,还是发病机理都有相同之处。
Objective: To study the relationship between anti-neutrophil cytoplasmic antibody (ANCA) and glomerulonephritis. Methods: Indirect immunofluorescence and enzyme-linked immunosorbent assay were used to qualitatively and quantitatively determine 48 cases of various types of glomerulonephritis with anti-neutrophil cytoplasmic antibody. Meanwhile, clinical, pathological and laboratory tests were performed. RESULTS: (1) ANCA was positive in 12 of 48 patients with glomerulonephritis; (2) clinical manifestations of ANCA-positive patients were different; (3) most of the glomeruli in ANCA-positive patients had crescent Formation, vascular lesions and interstitial inflammation; (4) TNF in ANCA-positive patients was higher than normal, and deposition of adhesion molecule VCAM-1 could be found in different parts of glomeruli. Conclusion: Some glomerulonephritis is actually a class of vasculitis, both pathological changes, or pathogenesis have in common.