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以半乳甘露聚糖为主要成分的瓜尔胶,具有良好的水溶性和高粘度.故作为治疗糖尿病、胆固醇过多症和肥胖症的药物,也日益得到广泛应用.其药理作用主要为降血糖和血脂.迄今论述对瓜尔胶降血糖的机理有(1)葡萄糖在肠内吸收或运输受抑制;(2)延缓胃排空速度;(3)影响消化道激素的分泌.降血脂的机理可能为抑制胆固醇在肠内的吸收或增加胆固醇向胆汁酸的转化,对药物的安全性也作了讨论,即使服用较大剂量的瓜尔胶,也未见有严重的副作用.
Guar gum which contains galactomannan as its main component has good water-solubility and high viscosity, and is also widely used as a medicine for treating diabetes, hypercholesterolemia and obesity, and its pharmacological action is mainly decreased Blood sugar and blood lipid.However, the mechanisms of hypoglycemic effect on guar gum are as follows: (1) glucose is inhibited in intestinal absorption or transport; (2) delay gastric emptying rate; (3) affect the secretion of gastrointestinal hormones. The mechanism may be to inhibit the absorption of cholesterol in the intestine or to increase the conversion of cholesterol to bile acids. The safety of the drug is also discussed, and no serious side effects are observed even with larger doses of guar.