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对５５例证实有ＨＰ感染的消化性溃疡患者胃粘膜活检的病理资料进行了研究。结果发现：胃溃疡，ＨＰ感染程度在窦部、体部之间无明显差异，造成全胃弥漫性损害，而对于十二指肠溃疡而言，ＨＰ感染主要在窦部、胃粘膜的炎症反应亦主要在窦部。两种溃疡相比较，在ＨＰ感染量无显著差异的前提下，胃溃疡患者胃窦部胃粘膜上皮细胞增生较显著（Ｐ＜０．０５），体部胃粘膜的肠上皮化生、淋巴细胞浸润及上皮细胞增生的程度均显著重于十二指肠溃疡患者，腺体萎缩程度亦较高。作者推论，造成十二指肠溃疡和胃溃疡的ＨＰ可能属于不同的菌株，并初步分析了这两种菌株的生物学行为。
The pathological data of gastric mucosal biopsy in 55 patients with peptic ulcer confirmed by HP infection were studied. The results showed that: gastric ulcer, HP infection in the sinus, the body between no significant differences, resulting in diffuse whole-stomach damage, while for duodenal ulcer, HP infection mainly in the sinus, gastric mucosal inflammatory response Also mainly in the sinus. Compared with the two kinds of ulcers, there was no significant difference in HP infection in gastric ulcer patients gastric epithelial cell proliferation significantly (P <0.05), gastric mucosal intestinal metaplasia, lymphocytes The degree of infiltration and epithelial cell proliferation were significantly higher in patients with duodenal ulcer, gland atrophy is also higher. The authors infer that HP, which causes duodenal ulcer and gastric ulcer, may belong to different strains, and preliminary analysis of the biological behavior of the two strains.