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为了解慢性胃病患者胃粘膜表面疏水性的改变及其可能的影响因素，检测了４５例糜烂性胃炎和消化性溃疡患者胃粘膜表面的接触角（ＣＡ）、粘膜总磷脂含量和胃液中磷脂酶Ａ_２（ＰＬＡ_２）水平，观察了幽门螺旋菌（ＨＰ）感染对它们的影响。结果显示正常胃窦粘膜表面ＣＡ为４６．８６±４．６６°，疾病组显著降低（Ｐ＜０．０１），其中ＨＰ阳性组又低于ＨＰ阴性组（Ｐ＜０．０１）；疾病组粘膜活检组织总磷脂含量减低（Ｐ＜０．０１），ＣＡ与ＨＰ感染程度及ＰＬＡ_２水平呈负相关（ｒ分别为－０．３９０及－０．４１５，均Ｐ＜０．０１），与总磷脂含量不相关。提示糜烂性胃炎、消化性溃疡患者有粘液疏水屏障功能减弱及粘膜磷脂代谢障碍。
In order to understand the changes of gastric mucosal surface hydrophobicity and its possible influencing factors in chronic gastritis patients, the contact angle (CA), the total mucosal phospholipid content and the phospholipase in gastric juice were detected in 45 patients with erosive gastritis and peptic ulcer A_2 (PLA_2) levels, the impact of Helicobacter pylori (HP) infection on them were observed. The results showed that the surface CA of normal gastric mucosa was 46.86 ± 4.66 °, the disease group was significantly lower (P <0.01), and the HP positive group was lower than the HP negative group (P <0.01) Mucosal biopsy tissue total phospholipid content decreased (P <0.01), CA and HP infection levels and PLA_2 levels were negatively correlated (r were -0.390 and -0.415, respectively, P <0.01), and total Phospholipid content is not relevant. Prompt erosive gastritis, peptic ulcer patients with mucus hydrophobic barrier dysfunction and mucosal phospholipid metabolism.