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目的比较分析病理数码断层图像(pathologicaldigitizedsectionalimage,PDSI)与CT扫描在猪肺挫伤诊断中的差异。方法采用BIMⅡ型生物撞击机制作小香猪肺挫伤模型,并于伤后6小时行CT断层摄影(层厚5mm),吸气末结扎气管后,行肺动脉冲洗及灌注。截取猪胸部并冰冻后,在-25℃低温实验室中用TK26350型数控铣床(铣切精度为1mm)逐层铣切,并逐层摄取猪胸部的连续断层图像数据,运用3Ddoctor软件分割数码断层图像并与对应层面CT扫描结果进行对比分析。结果CT扫描25层,采集PDSI167幅,对应的PDSI层面与CT图像基本吻合。PDSI上出血呈褐色改变。CT第14～18层提示肺中叶局限性挫伤出血,大小约为2.5cm×1.8cm×2.0cm,PDSI上相应部位出血区大小约为2.0cm×0.7cm×1.9cm。CT提示右肺中叶及下叶后外侧基底段为可疑的损伤区域,而在PDSI上,该区域呈形状不规则的大片深褐色出血改变,范围从第52层至114层。结论首次获得猪肺挫伤的数码断层图像集,CT表现与实际肺损伤之间存在差异,实际伤情较CT提示的重。PDSI的采集和研究对促进CT诊断水平有意义。
Objective To compare and analyze the difference between pathologicaldigitized sectional image (PDSI) and CT scan in the diagnosis of pulmonary contusion in pigs. Methods Pulmonary contusion model was established by BIM Ⅱ biological impact machine. CT scan (thickness 5 mm) was performed 6 hours after injury. Pulmonary artery flushing and perfusion were performed after inhalation and end of tracheal ligation. After intercepting the pig’s chest and freezing, it was cut layer by layer with TK26350 CNC milling machine (milling precision 1mm) in a low-temperature laboratory at -25 ℃, and the continuous chest tomographic image data were taken in layers. The 3Ddoctor software was used to segment the digital tomography The images were compared with CT scan results of the corresponding level. Results CT scan 25 layers, collecting PDSI 167, the corresponding PDSI level basically consistent with CT images. Bleeding on PDSI showed a brown change. 14th to 18th layers of CT suggest limited contusion hemorrhage in the middle of the lung with a size of about 2.5cm × 1.8cm × 2.0cm. The size of bleeding area at the corresponding site of PDSI is about 2.0cm × 0.7cm × 1.9cm. CT revealed a suspicious lesion area in the middle and right posterior lobe of the right lung, whereas in the PDSI the area showed irregularly large dark brown hemorrhage ranging from the 52nd to the 114th. Conclusion For the first time, the digital CT images of lung contusion were obtained. There was a difference between CT and actual lung injury. The actual injury was heavier than that of CT. PDSI acquisition and research to promote the diagnosis of CT level of significance.