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胰岛淀粉样多肽(islet amyloid polypeptide,IAPP)是1986年瑞典学者Westermark et al从胰岛素瘤患者的瘤组织,糖尿病猫及Ⅱ型糖尿病患者胰岛淀粉样沉积物中分离出来的一种多肽,几乎在同时,英国生物化学家Cooper et al也从Ⅱ型糖尿病患者的胰岛淀粉样沉积物中分离出该肽。IAPP又称为amylin,对IAPP的分子结构、基因表达和生理作用等已有许多报道。近年来,在IAPP定位、表达及胃肠胰IAPP免疫反应(immunoreactive,IR)细胞定位、发生、发育方面的研究报道,为探讨IAPP的生理作用及疾病状态下的改变,提供了形态学依据,现综述如下。
Islet amyloid polypeptide (IAPP) was isolated in 1986 by the Swedish scholar Westermark et al from pancreatic amyloid deposits from insulinoma patients, diabetic cats and type 2 diabetic patients. Almost simultaneously British biochemist Cooper et al also isolated this peptide from amylin deposits in patients with type 2 diabetes. IAPP, also known as amylin, has many reports on the molecular structure, gene expression and physiological functions of IAPP. In recent years, IAPP localization, expression and gastrointestinal pancreatic IAPP immune response (immunoreactive, IR) cell location, occurrence, development of research reports, in order to explore the physiological role of IAPP and disease status changes, provide a morphological basis, Are summarized below.