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目的探讨子宫内膜弥漫性大B细胞性淋巴瘤的临床病理特征及鉴别诊断要点。方法对1例子宫内膜弥漫性大B细胞性淋巴瘤进行临床病理检查,标本采用常规石蜡切片,HE和免疫组化染色,透射电镜观察,并复习相关文献。结果镜下可见病变组织中主要为中心细胞样和中心母细胞样形态的肿瘤细胞。免疫组化显示瘤细胞LCA、CD20、CD79α、lambda(),Ki-67阳性率为80%。电镜下肿瘤细胞数量多,排列紧密,体积较大,核大呈卵圆形,异染色质较多、边集,胞质内细胞器较少。结论发生于子宫内膜的恶性淋巴瘤很少见,该肿瘤的诊断和鉴别诊断主要依靠病理组织学和免疫组化。
Objective To investigate the clinicopathological features and differential diagnosis of diffuse large B-cell lymphoma in the endometrium. Methods One case of diffuse large B-cell lymphoma of endometrium was examined by clinicopathological examination. The specimens were examined by conventional paraffin sections, HE and immunohistochemistry staining and transmission electron microscopy, and the related literatures were reviewed. Results Microscopically, tumor cells in the diseased tissues were mainly centromeric and centroblastic. Immunohistochemistry showed that the positive rate of LCA, CD20, CD79α, lambda () and Ki-67 in tumor cells was 80%. Under electron microscope, the number of tumor cells was more, arranged closely, larger in size, larger in nucleus and ovoid in shape, more heterochromatin, less in or around the cytoplasm. Conclusions Malignant lymphoma occurred in the endometrium is rare. The diagnosis and differential diagnosis of the tumor rely mainly on histopathology and immunohistochemistry.