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目的探讨血管内皮生长因子C(VEGF-C)、淋巴管内皮细胞特异性标记物D2-40与结肠直肠癌淋巴结转移的关系。方法 56例结肠直肠癌患者中有淋巴结转移30例,无淋巴结转移26例。应用免疫组织化学染色方法检测肿瘤原发灶的VEGF-C、D2-40的表达情况。结果 56例结肠直肠癌患者中有、无淋巴结转移者的VEGF-C阳性表达率分别为73.3%、15.4%,两者比较,差异有统计学意义(P<0.05);有、无淋巴结转移者D2-40标记的淋巴管密度分别为33.2±2.3、21.4±1.6,两者比较,差异有统计学意义(P<0.05)。结论结肠直肠癌患者癌组织中VEGF-C、D2-40的表达与淋巴结转移相关。
Objective To investigate the relationship between vascular endothelial growth factor C (VEGF-C) and lymphatic endothelial cell specific marker D2-40 and lymph node metastasis in colorectal cancer. Methods 56 cases of colorectal cancer patients with lymph node metastasis in 30 cases, no lymph node metastasis in 26 cases. Immunohistochemical staining was used to detect the expression of VEGF-C and D2-40 in primary tumor. Results The positive expression rates of VEGF-C in 56 patients with colorectal cancer were 73.3% and 15.4% respectively, the difference was statistically significant (P <0.05). There was no lymph node metastasis The density of D2-40 labeled lymphatic vessels were 33.2 ± 2.3 and 21.4 ± 1.6, respectively, with significant difference (P <0.05). Conclusion The expression of VEGF-C and D2-40 in colorectal cancer is related to lymph node metastasis.