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目的:观察尼可地尔联合氨氯地平对不稳定性心绞痛(UA)患者治疗效果,为UA患者的临床治疗提供更多的科学理论依据.方法:将75例UA患者随机分为观察组42例和对照组33例.观察组在常规心绞痛治疗基础上加用尼可地尔联合氨氯地平,对照组给予常规心绞痛治疗基础上加用氨氯地平.6个月后观察两组的总有效率、缺血发作次数、ST段最大下降幅度及不良反应发生率.结果:观察组UA患者总有效率显著高于对照组,且不良反应显著低于对照组.差异均有统计学意义(P＜0.05).结论:在常规治疗基础上,加用尼可地尔联合氨氯地平能有效提高UA患者的临床疗效,缺血发作次数显著减少、ST段下降幅度明显,且不良反应少,利于患者的康复.“,”OBJECTIVE: To investigate the clinical efficacay of nicorandil with amlodipine on unstable angina pectoris ( UA) pa-tients in order to provide more scientific basis in the clinical treatment of UA patients.METHODS: 75 UA patients were randomly di-vided into the observation group (n=42) and control group (n=33).The observation group received the conventional treatment of angina pectoris combined with nicorandil plus amlodipine.And the control group accepted conventional treatment of angina pectoris combined with amlodipine.The changes of total effective rate,the number of ischemic attack,ST segement above the largest and the incidence of adverse effect were compared in two groups after 6 months.RESULTS: The total efficiency of UA patients in the observa-tion group was significantly higher than that in control group and the adverse reactions in the observation group were significantly lower than those in control group.There were statiscally significant difference (P＜0.05).CONCLUSION: On the conventional treatment,extra use of nicorandil combined with amlodipine can effectively increase the therapeutic effect of the patients with UA and ischemic at-tackfrequency and adverse effects are significantly reduced.