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目的正己烷接触员工相关指标研究。方法选取生产工艺和生产用油墨基本相同的3个(A、B、C)印刷车间,检测3个车间现场正己烷浓度,每个车间随机抽取40名员工,测定其神经传导速度(NCV)和红细胞膜收缩蛋白(Sp)的共价交联异常情况,并观察三者的关系。选择40名办公室员工作作对照。结果C车间部分员工正中神经传导速度减慢,当正己烷浓度>44.7 mg/m3时,吸光度扫描的共价交联Sp差异有统计学意义(分别与办公室员工、A车间员工比较,P<0.05)。结论高浓度正己烷可致神经源性损害,共价交联Sp作为正己烷神经毒性的替代生物标志物有一定研究价值。
Objective n-Hexane exposure to staff-related indicators. Methods Three (A, B, C) printing workshops with the same manufacturing process and production inks were selected to test the concentration of n-hexane in the three workshops. 40 workers were randomly selected from each workshop to measure the nerve conduction velocity (NCV) Erythrocyte membrane contraction protein (Sp) covalent cross-linked abnormalities, and observe the relationship between the three. Choose 40 office workers as a control. Results The median nerve conduction velocity slowed down in some employees of workshop C. When the n-hexane concentration was higher than 44.7 mg / m3, the difference of covalent cross-linking Sp in absorbance scanning was statistically significant (P <0.05 compared with employees in office and workshop A, respectively ). Conclusions High concentration of n-hexane can cause neurogenic damage. Covalent cross-linking Sp as a biomarker of n-hexane neurotoxicity has some research value.