AIM:To investigate clinical and pathologic data ofesophageal carcinoma(EC)and cardiac carcinoma(CC)among residents in Chaoshan region of China.METHODS:Clinical and pathologic data of 9 650 patientswith EC and 4 173 patients with CC in the Chaoshanpopulation were collected and analyzed.Moreover,Chaoshan esophageal carcinoma tissue arrays were madefor high-throughput study.RESULTS:Male to female ratio was 3:1 in patients withEC and 4.75:1 in CC.The average age of the occurrenceof EC was 54.6 years,and of CC was 58.1 years.For bothEC and CO,age at diagnosis was a little younger inChaoshan region than in most other areas.The mostcommonly affected site of esophageal carcinoma was themiddle third of esophagus(72.0%);the second was thelower third(15.3%).The main gross type of esophagealcarcinoma was ulcerative type(dl.50%);the medullary typewas the second(39.6%).Squamous cell carcinoma accountedfor the overwhelming majority of esophageal cancer(96.4%);adenocarcinoma accounted for the overwhelming majorityof cardiac carcinoma(94.5%).Chaoshan esophagealcarcinoma tissue arrays were easily for high-throughputstudy,and tissue cores with a diameter of 1.5 mm couldbetter keep more structure for molecular expression study.CONCLUSION:Both EC and CC are common in males.The average occurrence age of EC and CC is younger inChaoshan than in most other regions of China.The mostcommonly affected site of esophageal carcinoma was themiddle third of esophagus(72.0%).Squamous cell carcinoma accounted for the overwhelming majority ofesophageal cancer;adenocarcinoma accounted for theoverwhelming majority of cardiac carcinoma.Tissue arraystechnology is applicable for rapid molecular profiling oflarge numbers of cancers in a single experiment. To investigate clinical and pathologic data of esophageal carcinoma (EC) and cardiac carcinoma (CC) among residents in Chaoshan region of China. METHODS: Clinical and pathologic data of 9 650 patients with EC and 4 173 patients with CC in the Chaoshanpopulation were collected and The patients were analyzed for the high-throughput study. RESULTS: Female to female ratio was 3: 1 in patients with EC and 4.75: 1 in CC. The average age of the occurrence of EC was 54.6 years, and of CC was 58.1 years.For bothEC and CO, age at diagnosis was a little younger inChaoshan region than in most other areas. most mostly affected site of esophageal carcinoma was themiddle third of esophagus (72.0%); the second was thelower third (15.3%) The main gross type of esophageal carcinoma was ulcerative type (dl.50%); the medullary type was the second (39.6%); Squamous cell carcinoma accounted for the overwhelming majority of esophageal cancer moshan majority of cardiac carcinoma (94.5%). Chaoshan esophagealcarcinoma tissue arrays were easily for high-throughput study, and tissue cores with a diameter of 1.5 mm couldbetter keep more structure for molecular expression study. CONCLUSION: Both EC and CC are common in males. average occurrence age of EC and CC is younger inChaoshan than in most other regions of China. most mostly affected site of esophageal carcinoma was themiddle third of esophagus (72.0%). Squamous cell carcinoma accounted for the overwhelming majority of esophageal cancer; adenocarcinoma accounted for theoverwhelming majority of cardiac carcinoma. Tissue arraystechnology is applicable for rapid molecular profiling of large numbers of cancers in a single experiment.