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目的观察哌甲酯对注意缺陷多动障碍(ADHD)患儿EEG的影响,探讨其预测ADHD患儿疗效的可行性。方法对32例ADHD患儿服用哌甲酯治疗前及治疗后1周分别进行EEG检测,并比较其差异。结果 1.ADHD患儿服用哌甲酯前EEG异常率为71.87%。EEG主要表现为θ波、δ波增多,α波减少;θ/α及θ/β比值增加。2.ADHD患儿服用哌甲酯后,EEG异常率为40.62%,EEG表现为α波数量增加,全脑特别是额区θ波减少,θ/α、θ/β比值下降,额叶α波、β波增多,尤以右额、颞前、双侧枕部为显著。ADHD患儿服用哌甲酯后EEG异常率同服药前比较,差异有统计学意义(χ2=6.35,P<0.05)。结论 EEG可作为ADHD患儿对哌甲酯反应性的客观依据。
Objective To investigate the effect of methylphenidate on EEG in children with attention-deficit hyperactivity disorder (ADHD) and to explore the feasibility of predicting its efficacy in children with ADHD. Methods EEG was performed on 32 children with ADHD before taking methylphenidate and one week after treatment, and the differences were compared. Results 1.ADHD children taking methylphenidate EEG abnormalities before 71.87%. EEG mainly showed θ wave, δ wave increased, α wave decreased; θ / α and θ / β ratio increased. The abnormal EEG rate was 40.62% in patients with ADHD. The EEG showed the increase of α wave number, the decrease of θ wave, θ / α, θ / β ratio in the frontal area, , Β wave increased, especially in the right forehead, temporal anterior, bilateral occipital significant. The abnormal rate of EEG in children with ADHD after taking methylphenidate was significantly different from that before taking medicine (χ2 = 6.35, P <0.05). Conclusion EEG can be used as an objective basis for the reactivity of methylphenidate in children with ADHD.