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目的比较哌甲酯对注意缺陷多动障碍(ADHD)患儿治疗前后事件相关电位的影响。方法 ADHD患儿32例口服哌甲酯后应用丹迪Keypoint肌电-诱发电位仪进行Go/Nogo任务的事件相关电位检测,以30名健康儿童作为健康对照组,对事件相关电位主成分进行比较。应用SPSS 13.0软件进行统计学分析。结果 ADHD患儿服药后Go-P3潜伏期(355.16±17.04)ms,短于服药前(366.66±19.32)ms,但长于健康对照组(333.70±23.57)ms(Pa<0.05);波幅(5.88±1.72)μV,高于服药前(4.82±2.14)μV,但低于健康对照组(7.19±1.87)μV(Pa<0.05);ADHD患儿服药后Nogo-P3波幅(6.13±1.68)μV,高于服药前(5.04±1.76)μV,但低于健康对照组(8.32±2.03)μV(P<0.05,0.01)。结论哌甲酯能改善ADHD患儿的注意性及抑制性执行功能。
Objective To compare the effect of methylphenidate on event-related potentials in children with attention-deficit hyperactivity disorder (ADHD) before and after treatment. Methods Thirty-two children with ADHD were enrolled in this study. Event-related potentials of Go / Nogo task were detected by Dandy Keypoint electromyography-evoked potential meter. Thirty healthy children were used as healthy controls to compare the main components of event-related potentials . SPSS 13.0 software was used for statistical analysis. Results The latency of Go-P3 in children with ADHD was (355.16 ± 17.04) ms, shorter than that before treatment (366.66 ± 19.32) ms but longer than that of healthy control (333.70 ± 23.57) ms (P0.05) ) (P <0.05). The amplitude of Nogo-P3 in children with ADHD was (6.13 ± 1.68) μV, which was higher than that before treatment (4.82 ± 2.14) μV but lower than that of healthy control group (7.19 ± 1.87) μV Before treatment (5.04 ± 1.76) μV, but lower than the healthy control group (8.32 ± 2.03) μV (P <0.05,0.01). Conclusion Methylphenidate can improve the attention and inhibitory performance of ADHD children.