论文部分内容阅读
白介素10(IL-10)最初被认为是一种细胞因子合成抑制剂。目前认为,IL-10在免疫系统中作用广泛,包括刺激作用和抑制作用,但主要是起抑制作用。除此之外,IL-10还对神经内分泌活动起作用。可由鼠垂体细胞产生并能诱导鼠垂体及脾细胞产生促肾上腺素(ACTH)。ACTH促进肾上腺皮质激素的分泌,起免疫抑制作用。所以,IL-10可能通过两种机制来抑制机体的免疫功能,即通过直接抑制细胞因子的合成和间接通过促进ACTH的分泌而起作用。
Interleukin 10 (IL-10) was originally recognized as a cytokine synthesis inhibitor. It is currently believed that IL-10 has a wide range of roles in the immune system, including stimulatory and inhibitory effects, but primarily suppressive effects. In addition, IL-10 also plays a role in neuroendocrine activity. Pituitary cells can be produced and can induce murine pituitary and spleen cells produce adrenaline (ACTH). ACTH promote the secretion of adrenal cortex hormones, immunosuppressive effect. Therefore, IL-10 may inhibit the body’s immune function through two mechanisms, namely, by directly inhibiting the synthesis of cytokines and indirectly by promoting the secretion of ACTH.