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本文应用抗增殖细胞核抗原/周期素的单克隆抗体PC10,以ABC免疫组织化学方法对49例膀胱移行细胞癌作了研究,并与组织学分级和预后作了对比分析,结果发现:移行细胞癌各级间比较PCNA表达率存在着极显著性差异(P<0.01).PCNA表达强级(>76％)与弱级(<75％)之间比较生存率存在着极显著性差异(P<0.01).结果提示:此方法是在福尔马林固定,石蜡包埋的移行细胞癌切片上检测细胞增殖分数的一个可靠手段,并可能是判断移行细胞癌预后的一个新指标.
In this paper, anti-proliferating cell nuclear antigen / cyclin monoclonal antibody PC10, ABC immunohistochemistry in 49 cases of bladder transitional cell carcinoma was studied and compared with the histological grade and prognosis were compared and found that: transitional cell carcinoma There was a significant difference in the expression rates of PCNA among different grades (P <0.01), and there was a significant difference in the relative survival rates between PCNA expression level (> 76%) and weak level (<75%) (P < 0.01) .The results suggest that this method is a reliable method to detect the cell proliferation fraction in formalin-fixed paraffin-embedded transitional cell carcinoma and may be a new indicator to judge the prognosis of transitional cell carcinoma.