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目的 调查胃癌患者ｐ１６基因的改变。方法采用ＰＣＲ方法，对２３例胃癌患者肿瘤组织标本进行ｐｌ６基因外显子３的缺失研究。结果发现２例弥漫型胃癌有 ｐ１６基因的纯合缺失，缺失频率为８．７０％。结论证明ｐ１６基因的改变与胃癌的发生和发展有一定的联系。
Objective To investigate the alteration of p16 gene in gastric cancer patients. Methods The deletion of exon 3 of pl6 gene was studied in 23 specimens of gastric cancer patients by PCR. The results showed that 2 cases of diffuse gastric cancer had a homozygous deletion of p16 gene with a deletion frequency of 8.70%. Conclusions There is a certain relationship between the changes of p16 gene and the occurrence and development of gastric cancer.