论文部分内容阅读
目的:筛选与转移相关的大肠癌分子标签。方法:本文通过对大肠癌表达谱数据进行分析,按照表达谱中大肠癌转移情况,组织学分化程度以及患者生存时间进行显著性分析,将与大肠癌转移相关的具有显著性意义的基因群进行聚类,通过主成分分析以及自组织映射的方法计算出差异表达基因中,起着主体分类作用的基因群。结果:筛选出与肿瘤组织分化程度以及患者生存时间相关的差异表达基因,进行功能富集,并筛选出了一批与大肠癌转移密切相关的重要基因,这些基因对大肠癌早期诊断,及时治疗,预后评估有着重要意义。结论:细胞代谢,趋化因子信号通路和细胞因子受体等分子事件与大肠癌分化程度密切相关,是否发生转移与大肠癌的预后生存期密切相关。
Objective: To screen molecular markers associated with metastasis of colorectal cancer. Methods: The expression profiles of colorectal cancer were analyzed, and according to the expression profiles of colorectal cancer metastasis, histological differentiation and survival time of patients were significantly analyzed, the colorectal cancer metastasis-related significant group of genes were carried out Clustering, through principal component analysis and self-organization mapping method to calculate the differentially expressed genes, plays a main role in the classification of the gene group. Results: The differentially expressed genes related to the degree of tumor differentiation and the survival time of patients were screened for functional enrichment and a number of important genes closely related to the metastasis of colorectal cancer were screened out. These genes were useful for the early diagnosis and timely treatment of colorectal cancer Prognostic assessment is of great significance. CONCLUSION: Molecular events such as cell metabolism, chemokine signaling and cytokine receptors are closely related to the degree of differentiation of colorectal cancer. The occurrence of metastasis is closely related to the prognosis of colorectal cancer.