Electrochemical oxidation (EO) is a promising technique for decentralized wastewater treatment,owing to its modular design,high efficiency,and ease of automation and transportation.The catalytic destruction of recalcitrant,non-biodegradable pollutants (per-and poly-fluoroalkyl substances (PFAS),pharmaceuticals,and personal care products (PPCPs),pesticides,etc.) is an appropriate niche for EO.EO can be more effective than homogeneous advanced oxidation processes for the degradation of recalcitrant chemicals inert to radical-mediated oxidation,because the potential of the anode can be made much higher than that of hydroxyl radicals (EOH =2.7 V vs.NHE),forcing the direct transfer of electrons from pollutants to electrodes.Unfortunately,at such high anodic potential,chloride ions,which are ubiquitous in natural water systems,will be readily oxidized to chlorine and perchlorate.Perchlorate is a to-be-regulated byproduct,and chlorine can react with matrix organics to produce organic halogen compounds.In the past ten years,novel electrode materials and processes have been developed.However,spotlights were rarely focused on the control of byproduct formation during EO processes in a real-world context.When we use EO techniques to eliminate target contaminants with concentrations at μg/L-levels,byproducts at mg/L-levels might be produced.Is it a good trade-oft?.Is it possible to inhibit byproduct formation without compromising the performance of EO? In this minireview,we will summarize the recent advances and provide perspectives to address the above questions.