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目的:探讨γ-谷氨酰转移酶(GGT)与急性ST段抬高型心肌梗死(STEMI)溶栓再通后住院期间主要不良心血管事件(MACE)的关系。方法:回顾性分析2010年1月至2015年6月在我院住院的STEMI溶栓再通后患者149例,根据住院期间是否发生MACE分为MACE组35例及非MACE组114例,记录患者一般临床资料、MACE发生率,采用t检验及Logistic回归分析GGT与STEMI溶栓再通后MACE的关系。结果:与非MACE组比较,MACE组年龄、糖尿病患病率、发病到血管再通时间、收缩压及心肌梗死面积、血糖(GLU)、肌钙蛋白I(c Tn I)、GGT、尿酸(UA)水平明显升高(P<0.05);Logistic回归显示GGT为STEMI溶栓再通后住院期间发生MACE的独立危险因素。结论:随着GGT水平升高,STEMI溶栓再通后MACE发生率明显升高,GGT是STEMI溶栓再通后住院期间发生MACE的独立危险因素。
Objective: To investigate the relationship between γ-glutamyl transferase (GGT) and major adverse cardiovascular events (MACE) during hospitalization after acute thrombolysis with ST-segment elevation myocardial infarction (STEMI). Methods: A total of 149 STEMI-recanalization patients admitted to our hospital from January 2010 to June 2015 were retrospectively analyzed. According to whether MACE occurred during hospitalization, MACE patients were divided into MACE group (n = 35) and non-MACE group (n = 114) General clinical data, MACE incidence, using t test and Logistic regression analysis of GGT and STEMI thrombolysis after re-association of MACE. Results: Compared with non-MACE group, age, prevalence of diabetes, incidence of recanalization time, systolic blood pressure and myocardial infarct size, blood glucose (GLU), cTn I, GGT, uric acid UA) (P <0.05). Logistic regression showed that GGT was an independent risk factor for MACE during hospitalization after STEMI thrombolysis recanalization. CONCLUSION: With the increase of GGT level, the incidence of MACE after thrombolysis recanalization is significantly increased. GGT is an independent risk factor for MACE during STEMI reperfusion after hospitalization.