AIM:To elucidate the clinical and laboratory features oflocalized gastric amyloidosis via a rare report along with areview of related literatures.METHODS:The clinical manifestations,laboratory resultsand surgical treatment of a female patient with localizedgastric amyloidosis in our hospital were summarized.Therelevant literatures were reviewed on the etiology,clinicalfeatures,diagnosis,treatment and prognosis of this disease.RESULTS:The patient was lack of specific clinicalmanifestations and positive laboratory results.Prior to thetreatment,she was suspected to be of malignization fromgastric ulcer by both gastroscopy and endoscopicultrasonography,which was denied by the gastric biopsy.The patient was treated with subtotal gastrectomy andclearance of perigastric lymph nodes.The postoperativepathological diagnosis determined the lesion to be thedeposition of amyloid materials in the gastric mucosa,submucosa and blood vessel walls with intestinal metaplasiaand atrophy of the gastric glands,in which no malignanttumor was found.Congo red staining with prior potassiumpermanganate incubation confirmed the AA type of amyloidin this case.Multiple biopsies from esophagus,remnantstomach,duodenum,colon and bone marrow in the follow-up survey showed no amyloidal deposition in these tissuesand organs.Up to the present,no signs of recurrence havebeen found in this patient.CONCLUSION:Localized gastric amyloidosis,being rare inincidence,should be considered in the differentiation ofgastric tumors,in which biopsy is the only means to confirmthe diagnosis.Currently,surgical resection of pathologicaltissue and circumambient lymph nodes may be a preferabletherapeutic strategy for the localized amyloidosis to preventpossible complications.Although with a benign prognosis,gastric amyloidosis possesses a recurrent tendency assuggested by the literatures. AIM: To elucidate the clinical and laboratory features of localized carboal amyloidosis via a rare report along with are view of related literatures. METHODS: The clinical manifestations, laboratory results and surgical treatment of a female patient with localized gastrointestinal amyloidosis in our hospital were summarized. on the etiology, clinicalfeatures, diagnosis, treatment and prognosis of this disease .RESULTS: The patient was lack of specific clinicalmanifestations and positive laboratory results. Prior to the treatment, she was suspected to be of malignation fromgastric ulcer by both gastroscopy and endoscoprasionography, which was denied by the gastric biopsy.The patient was treated with subtotal gastrectomy andclearance of perigastric lymph nodes. The postoperativepathologicaldiagnostics the lesion to be thedeposition of amyloid materials in the gastric mucosa, submucosa and blood vessel walls with intestinal metaplasia and atrophy of the gastric gla nds, in which no malignant tumor was found. Cito red staining with prior potassium permanganate incubation confirmed the AA type of amyloidin this case. Multiple biopsies from esophagus, remnantstomach, duodenum, colon and bone marrow in the follow-up survey showed no amyloidal deposition in these tissuesand organs.Up to the present, no signs of recurrence havebeen found in this patient. CONCLUSION: Localized gastric amyloidosis, being rare inincidence, should be considered in the differentiation ofgastric tumors, in which biopsy is the only means to confirm the diagnosis. Current, surgical resection of pathological tissue and circumambient lymph nodes may be a preferred therapeutic strategy for the localized amyloidosis to preventpossible complications. Although with a benign prognosis, gastric amyloidosis possesses a recurrent tendency assuged by the literatures.