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目的分析探讨农村地区血清同型半胱氨酸(Hcy)水平与既往脑卒中的关系。方法使用“卫生部脑卒中筛查与防治工程委员会”下发的《社区脑卒中高危人群发病和脑卒中再发风险评估表》,对北京市朝阳区王四营乡40岁及以上的北京市常住人口进行脑卒中风险筛查。对被评估为高危的筛查对象,做进一步的血清Hcy水平检测和颈动脉B超检查。结果共筛查5 027人,其中高危者1 676人。高危人群的血清Hcy平均水平为18.88±8.02μmol/L,男性高于女性,且随年龄增加而增高(P<0.05);高危人群中Hcy水平既往脑卒中组高于无脑卒中病史组,经多因素Logistic回归分析,提示性别、年龄和血清Hcy水平可能是既往脑卒中患病的危险因素。结论脑卒中高危人群血清Hcy水平普遍偏高(>10μmol/L),且既往脑卒中者血清Hcy水平高于无脑卒中病史者,性别、年龄和血清Hcy水平可能是既往脑卒中患病的危险因素。
Objective To analyze the relationship between serum homocysteine (Hcy) levels and past stroke in rural areas. Methods The risk assessment of high risk of stroke and stroke recurrence in community was issued by the Committee of Stroke Screening and Prevention and Control of the Ministry of Health. Resident population in Beijing stroke risk screening. To be assessed as a high risk screening object, further serum Hcy levels and carotid ultrasound examination. Results A total of 5 027 people were screened, of whom 1 676 were high risk. Serum Hcy levels in high-risk groups were 18.88 ± 8.02μmol / L, higher in males than in females, and increased with increasing age (P <0.05). Hcy in high-risk groups was higher than in previous stroke-free groups, Multivariate Logistic regression analysis suggested that sex, age and serum Hcy levels may be the risk factors of previous stroke. Conclusions Serum Hcy level is generally high (> 10μmol / L) in high-risk stroke population, and the serum Hcy level in previous stroke patients is higher than that without stroke history. The gender, age and serum Hcy level may be the risk of previous stroke factor.