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干扰素(INF-α和β)引起细胞的抗病毒状态出现很快,6～7h后即可完全保护细胞.该状态在洗去IFN后可保持9～12h,48h后仍有一定的保护作用.IFN-γ与IFN-α和β不同,它引起细胞的抗病毒状态要慢得多,24h后才能完全保护细胞.比较三种浓度的IFN-α时,可见5IU/ml不能完全保护细胞,而250IU/ml和25IU/ml时的抗病毒状态的动力学变化是一致的.该病毒状态可被加入的抗IFN-α血清抑制,但必须在该状态形成前加入.这些结果对临床工作者在制订治疗方案时将是有用的参考.
Interferon (INF-α and β) caused the cells to have an antiviral status appeared quickly, and could completely protect the cells after 6 ~ 7h.The status could be maintained for 9 ~ 12h after washing IFN, and still have some protective effect after 48h .IFN-γ, unlike IFN-α and β, causes a much slower antiviral state of the cells and completely protects the cells after 24 h. When comparing IFN-α concentrations at 3 concentrations, 5 IU / ml did not completely protect cells, While the kinetics of antiviral status were consistent at 250 IU / ml and 25 IU / ml.The virus status was inhibited by the addition of anti-IFN-α serum, but it must be added before the state was formed.These results are useful for clinicians It will be a useful reference when formulating treatment options.