作者联合应用人γ-干扰素(HuIFN-γ)和人γ-干扰素(天然或重组)或人β-干扰素(HuIFN-β),对IFN在转化的人羊膜WISH细胞、正常的二倍体纤维母细胞(Fs-4)和21三体纤维母细胞(Gm2767)的抗病毒和抗细胞活性进行了研究,结果如下:采用空斑试验法测定病毒产量,判断IFN的抗病毒活性,当HuIFN-α、β和γ以不同浓度(5、2.5和1.0U/ml)分别作用于WISH细胞,都能诱导抗病毒活性,且HuIFN-γ的作用比HuIFN-α或β强.以等浓度(2.5U/ml) The authors co-administered human interferon-gamma (HuIFN-γ) and human γ-interferon (native or recombinant) or human interferon-beta (HuIFN-β) to normalized IFN in transformed human amniotic WISH cells The antiviral and anti-cell activities of somatic fibroblasts (Fs-4) and trisomy 21 (Gm2767) were studied. The results were as follows: The viral production was determined by plaque assay to determine the antiviral activity of IFN when The effect of HuIFN-α, β and γ on WISH cells induced by different concentration (5, 2.5 and 1.0 U / ml) was stronger than that of HuIFN-α or β, (2.5 U / ml)