应用Ｂａｙｅｓｉａｎ反馈法预测２１例高血压病人，口服阿替洛尔的个体药动学参数及稳态血药浓度（Ｃｐｓｓ）并与经典药动学方法估算结果作比较，结果表明本法的Ｔ１／２为６．０±１．７ｈ，Ｖｄ为１．４３±０．１３Ｌ／ｋｇ，ＣＬ为１７２±３４ｍｌ／（ｈ·ｋｇ）；经典法的Ｔ１／２为６．８±２．４ｈ，Ｖｄ为１．４５±０．５６Ｌ／ｋｇ，ＣＬ为１６４±８５ｍｌ／（ｈ·ｋｇ）。两者无显著性差异（Ｐ＞０．０５）。两法所测得Ｃｐｓｓ有较好相关性（ｒ＝０．９９３）。 Bayesian feedback method was used to predict the individual pharmacokinetic parameters and steady-state plasma concentration (Cpss) of 21 patients with atenolol and oral atenolol, and compared with the results of classical pharmacokinetic methods. The results showed that T1 / 2 was 6.0 ± 1.7 h, Vd was 1.43 ± 0.13 L / kg, CL was 172 ± 34 ml / (h · kg); T1 / 2 of the classical method was 6.8 ± 2.4 h, Vd Was 1.45 ± 0.56 L / kg, CL was 164 ± 85 ml / (h · kg). There was no significant difference between the two (P> 0.05). Cpss measured by the two methods has a good correlation (r = 0.993).