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观察了实验性糖尿病大鼠早期肾功能、ＲＡ系统和前列腺素的改变，发现在糖尿病形成８天后尿蛋白排泄量明显增加，用Ｃａｐｔｏｐｒｉｌ后与正常对照组无差异。ＧＦＲ和ＲＰＦ明显增加，用Ｃａｐｔｏｐｒｉｌ或消炎痛后与正常组无差异。血浆肾素活性和血管紧张素Ⅱ浓度明显减低，用Ｃａｐｔｏｐｒｉｌ后血浆肾素活性与正常组无差异，但血管紧张素Ⅱ浓度仍继续减低。尿中ＰＧＥ２、６－ｋｅｔｏ－ＰＧＦ１α和ＴＸＢ２排泄明显增加，用消炎痛后降低至正常水平以下。上述结果提示ＲＡ系统和前列腺素均参与了糖尿病早期肾脏高功能状态的形成。
The changes of early renal function, RA system and prostaglandin in experimental diabetic rats were observed. Urine protein excretion increased significantly after 8 days of diabetes mellitus, but no difference with Captopril. GFR and RPF increased significantly, with Captopril or indomethacin no difference with the normal group. Plasma renin activity and the concentration of angiotensin Ⅱ decreased significantly. Plasma renin activity after Captopril was similar to that of the normal group, but the concentration of angiotensin Ⅱ continued to decrease. Excretion of urinary PGE2,6-keto-PGF1α and TXB2 significantly increased, with indomethacin reduced to below normal levels. The above results suggest that both RA system and prostaglandins are involved in the formation of high-status diabetic nephropathy.