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本文用生物素标记HBV-DNA探针对50例慢性活动性肝炎患者肝组织进行了原位分子杂交研究。结果发现:阳性物质主要存在于肝细胞浆内,并常呈带状分布于胞浆一侧,而胞核阳性则较少。阳性肝细胞可呈弥漫、局灶和散在性分布,却无明显变性、坏死。此外,还发现有些阳性物质恰“跨过”两紧邻肝细胞膜,略呈对称性分布于两侧,中间只见肝细胞膜隔开(梅花状)。这种现象
In this paper, biotinylated HBV-DNA probe in 50 patients with chronic active hepatitis liver tissue in situ hybridization study. The results showed that: positive substances mainly exist in the liver cytoplasm, and often ribbon-like distribution in the cytoplasm side, while the positive nuclei are less. Positive hepatocytes can be diffuse, focal and scattered distribution, but no significant degeneration and necrosis. In addition, it was found that some positive substances just “across” two adjacent liver cell membrane, slightly symmetrical distribution in the middle, only to see the liver cell membrane separated (plum-like). this phenomenon