Objective:To investigate the clinical efficacy of orthodromic island flap prosthetics of homo-digital artery on ifnger-tip defect. Methods: A total of 21 patients with ifnger-tip defect from December, 2010 to April, 2013 were given orthodromic island lfap prosthetics of homo-digital artery, with the maximum and minimum sizes of lfaps being 20 mm×22 mm and 10 mm×15 mm, respectively. Results: All patients with ifnger-tip defect survived from the lfap surgery and the wounds were favorably healed. 3~12 months follow-up after operation, the lfaps were observed with approving appearance, soft texture and favorable elasticity, with two-point discrimination being 6~8 mm. According to TAM detection of hand functions, lfaps were excellent healed in 19 cases, good and fairish in 1 case respectively, with effective rate being 95.2%. Conclusion:Orthodromic island flap prosthetics of homo-digital artery is simple and safe in operation with satisfactory effcacy, being the most ideal method for the repair of ifnger-tip defect.