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目的探讨庚型肝炎病毒（ＨＧＶ）在庚型肝炎肝组织中的表达状况与临床意义．方法应用免疫组织化学ＰＡＰ方法以鼠抗ＨＧＶＮＳ５单克隆抗体对庚型肝炎患者２０例（急性肝炎２例，慢性肝炎８例，肝硬变１０例，血清ＨＧＶＲＮＡ皆阳性）肝组织中ＨＧＶ抗原进行检测．结果庚型肝炎患者２０例中，８例（４０％）肝组织中检出ＨＧＶ抗原；不同病期检出率分别为：急性肝炎０／２（０％），慢性肝炎２／８（２５％），肝硬变６／１０（６０％），各组间差异无显著意义；阳性信号位于肝细胞胞质；阳性细胞可位于炎症坏死灶周围；抗原阳性与阴性组间肝组织炎症活动度及血清谷丙转氨酶水平无明显差别，但阳性组纤维化指数较高．结论ＨＧＶ感染及其在肝组织中表达可能与肝组织纤维化有一定关系
Objective To investigate the expression and clinical significance of hepatitis G virus (GG) in hepatic tissue of patients with hepatomegaly. Methods The anti-HGVNS5 monoclonal antibody was used to detect the HGV antigen in 20 patients (2 acute hepatitis, 8 chronic hepatitis, 10 cirrhosis, all serum HGVRNA positive) in hepatic tissue of hepatitis G patients by immunohistochemical PAP method . Results Among the 20 patients with G hepatitis, HGV antigen was detected in 8 (40%) liver tissues. The detection rates of HGV were 0/2 (0%) in acute hepatitis and 2/8 (25% ), Cirrhosis 6/10 (60%). There was no significant difference between the groups. The positive signal was located in the cytoplasm of hepatocytes. The positive cells could be located around the inflammatory necrosis. Serum alanine aminotransferase levels no significant difference, but the positive group higher fibrosis index. Conclusion HGV infection and its expression in liver tissue may be related to liver fibrosis