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目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者病情严重程度与甲状腺激素测定结果、D-二聚体、CRP相关性及其临床价值。方法选择2010年1月～2012年1月某院住院确诊AECOPD患者60例(有呼吸衰竭的30例,无呼吸衰竭30例)与30例对照组(非AECOPD患者)的血浆甲状腺激素定量结果、D-二聚体、CRP进行比较。结果 AECOPD患者(呼吸衰竭组)血浆甲状腺激素定量结果、D-二聚体、CRP明显高于AECOPD(无呼吸衰竭组),差异有统计学意义(P﹤0.05),也明显高于对照组,差异有统计学意义(P﹤0.05),COPD(无呼吸衰竭组)也高于对照组,差异有统计学意义(P﹤0.05)。结论 AECOPD患者血浆甲状腺激素水平明显降低,D-二聚体及CRP明显升高,并且其降低及升高程度与AECOPD严重程度相关,可作为AECOPD病情严重程度的判定指标之一。
Objective To investigate the relationship between the severity of the disease and the results of thyroid hormone test, D-dimer and CRP in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and its clinical value. Methods From January 2010 to January 2012 in a hospital diagnosed AECOPD patients 60 cases (30 cases of respiratory failure, no respiratory failure in 30 cases) and 30 cases of control group (non-AECOPD patients) of plasma thyroid hormone quantitative results, D-dimer, CRP for comparison. Results The quantitative results of plasma thyroid hormones, D-dimer and CRP in patients with AECOPD (respiratory failure group) were significantly higher than those in AECOPD (no respiratory failure group), the difference was statistically significant (P <0.05) The difference was statistically significant (P <0.05), COPD (no respiratory failure group) was also higher than the control group, the difference was statistically significant (P <0.05). Conclusions The level of plasma thyroid hormone and the level of D-dimer and CRP in patients with AECOPD are significantly lower than those in patients with AECOPD. The level of D-dimer and CRP is associated with the severity of AECOPD and may be used as a criterion for determining the severity of AECOPD.