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Objective: Intraperitoneal (IP) chemotherapy through subcutaneous port is an effective treatment for gastric cancer (GC) patients with peritoneal metastasis (PM).The objective of this study is to assess the port complications and risk factors for complications in GC patients with PM.Methods: In retrospective screening of 301 patents with subcutaneous ports implantation,249 GC patients with PM who received IP chemotherapy were screened out for analysis.Port complications and risk factors for complications were analyzed.Results: Of the 249 analyzed patients,57 (22.9％) experienced port complications.Subcutaneous liquid accumulation (42.1％) and infection (28.1％) were the main complications,and other complications included port rotation (14.1％),wound dehiscence (12.3％),inflow obstruction (1.7％) and subcutaneous metastasis (1.7％).The median interval between port implantation and occurrence of complications was 3.0 months.East Cooperative Oncology Group (ECOG) performance status[odds ratio (OR),1.74;95％ confidence interval (95％ CI),1.12-2.69],albumin (OR,3.67;95％ CI,1.96-6.86),implantation procedure optimization (OR,0.33;95％ CI,0.18-0.61) and implantation groups (OR,0.37;95％ CI,0.20-0.69) were independent risk factors for port complications (P＜0.05).ECOG performance status was the only factor that related to the grades of port complications (P=0.016).Conclusions: Port complications in GC patents who received IP chemotherapy are manageable.ECOG performance status,albumin,implantation procedure and implantation group are independent risk factors for port complications in GC patients with PM.