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应用微生物法测定６名健康志愿者多次口服氧氟沙星片达稳态后的血清药物浓度，药物体内过程符合一室模型，其主要药物动力学参数分别为：Ｔ＿（１／２）＝３．７４±０．４６ｈ；Ｖｃ＝１．５９±０．４５Ｌ／ｋｇ；Ｃ＿（ｍａｘ）＝２．６２±０．４２μｇ／ｍｌ；Ｔｐ＝１．２±０．５５ｈ。测定方法平均回收率为９９．２％。
The serum concentrations of ofloxacin tablets after steady oral administration were determined by the method of microbe in six healthy volunteers. The in vivo process of the drug met the one-compartment model. The main pharmacokinetic parameters were as follows: T 1/2 (1/2) = 3.74 ± 0.46 h; Vc = 1.59 ± 0.45 L / kg; C max = 2.62 ± 0.42 μg / ml; Tp = 1.2 ± 0.55 h. Determination of the average recovery rate of 99.2%.