本文报道依诺沙星、环丙沙星、氧氟沙星及培氟沙星单剂口服４００ｍｇ后药代动力学研究结果。用ＨＰＬＣ法测定血清药物浓度。口服后４种药物体内过程均符合一室开放模型。各种药物Ｃ＿（ｍａｘ）（μｇ／ｍｌ）与Ｔ＿（１／２）ｋｅ（ｈ）为依诺沙星２．４７和２．３５，环丙沙星２．１和２．９３，氧氟沙星４．４１和３．７４，培氟沙星６．７４和１３．３５。故口服４００ｍｇ依诺沙星、环丙沙星及氧氟沙星日２次，培氟沙星日１－２次，可用于治疗各种常见感染。 This article reports enoxacin, ciprofloxacin, ofloxacin and pefloxacin single oral dose of 400mg pharmacokinetic study results. Serum drug concentration was determined by HPLC method. After oral administration of four kinds of drugs in vivo processes are in line with a room open model. C_ (max) (μg / ml) and T_ (1/2) ke (h) of all drugs were 2.47 and 2.35 for enoxacin, 2.1 and 2.93 for ciprofloxacin, Shaoxing 4.41 and 3.74, Pefloxacin 6.74 and 13.35. Therefore, oral enrofloxacin 400mg, ciprofloxacin and ofloxacin 2 times, pefloxacin 1-2 times a day, can be used to treat various common infections.