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以原代肝细胞、肝细胞癌（Hepatocellularcarcinoma，HCC）细胞及对人工基底膜Matrigel具有侵袭能力的HCC细胞（HCC-Inv细胞）为研究对象，研究了三种细胞的粘弹特性、与胶原蛋白Ⅰ的粘附力学特性及与肝血窦内皮细胞（Liversinosoidalendothelialcell，LEC）的粘附力学特性。结果发现，HCC细胞的上述流变特性较之于肝细胞发生明显的变化；与肝细胞及HCC细胞相比较，HCC－Inv细胞表现出高的粘弹特性，高的与胶原蛋白Ⅰ的粘附力，高的与LEC的粘附力；免疫细胞化学的结果证实了HCC细胞与HCC－Inv细胞形态与细胞骨架结构的差异。作者对肝癌细胞流变特性改变及病理学意义作了简要讨论。
Primary hepatocytes, hepatocellular carcinoma (HCC) cells, and HCC cells (HCC-Inv cells) that have invasive ability to the artificial basement membrane Matrigel were studied to investigate the viscoelastic characteristics of three cells and collagen. The adhesion mechanics of I and its adhesion to hepatic sinusoidal endothelial cells (LECs). As a result, it was found that the above-mentioned rheological characteristics of HCC cells were significantly changed compared with that of hepatocytes; HCC-Inv cells exhibited high viscoelastic properties and high adhesion to collagen I compared with hepatocytes and HCC cells. Force, high adhesion to LEC; results of immunocytochemistry confirmed differences in morphology and cytoskeletal structure between HCC cells and HCC-Inv cells. The authors briefly discussed the changes in the rheological properties of liver cancer cells and their pathological significance.