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机体内一氧化氮(NO)是左旋精氨酸(L-arginine)与氧气经一氧化氮合酶(NOS)作用而产生的一种活性气体,适当浓度的NO可通过NO-cGMP途径调控心肌细胞ATP敏感性钾通道(KATP)的功能,调节心肌细胞对组织缺血缺氧的耐受性,参与心肌细胞的自身保护机制。NO生成不足与高血压、动脉粥样硬化、心力衰竭、糖尿病、高脂血症等心血管疾病的发生有关;NO生成和释放增多也可直接参与多种疾病的发生和发展,即NO与心功能密切相关,对多种疾病有重要的病理生理作用和临床意义。
Nitric oxide (NO) in the body is an active gas produced by the action of L-arginine and oxygen on nitric oxide synthase (NOS). NO at a suitable concentration can regulate the myocardium through the NO-cGMP pathway Cell ATP-sensitive potassium channel (KATP) function, regulate cardiomyocyte tolerance to tissue ischemia and hypoxia, involved in cardiomyocyte self-protection mechanism. The lack of NO production is associated with the development of cardiovascular diseases such as hypertension, atherosclerosis, heart failure, diabetes and hyperlipidemia. NO production and release increase may also be directly involved in the occurrence and development of various diseases, namely NO and heart Function is closely related to a variety of diseases have important pathophysiological effects and clinical significance.