PURPOSE: The purpose of this study was to assess the possibility of measuring radiation dose based on primary color chrominance in chemical solutions. METHODS: We used an aqueous solution with different concentrations of Alphaurine A and Tracid Brilliant Red B. This was irradiated by 1.5-13.5kGy 60Co γ radiation. Data were collected by an instrument that can detect information on the three primary colors. Data were analyzed and manipulated for each experiment. RESULTS AND CONCLUSIONS: The result shows that three primary colors chrominance in the aqueous solutions change with different doses of 60Co γ-rays and different concentrations of Alphaurine A and Tracid Brilliant Red B. For Alphaurine A, the red chrominance is gradually reduced as a function of radiation dose. The blue chrominance gradually increases concurrently. The red and green chrominance changes obviously and inversely, but the green chrominance changes little. In Tracid Brilliant Red B solution, the red chrominance and green chrominance gradually decreases as the radiation dose increases. And the changes are obvious and inverted. The blue chrominance changed little. Our experiments demonstrate that radiation dose can be studied based on three primary colors chrominance. This may be a new tool to measure radiation dose.