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胸部手术后常发生房性心律失常,肺切除术后患者出现心房纤颤提示预后不良.病死率可达25%。为此,作者实施了一次前瞻性随机研究计划包括100例肺切除术及200例肺叶切除术病人以评定胺碘酮、异搏定及安慰剂在预防性地治疗心房纤颤的作用。由于有3例肺切除患者术后胺碘酮治疗组病人发生危及生命的严重副作用,因而停止继续试验。此时,肺叶切除术后已有64例病人,肺切除术后有32例病人。3例ARDS(都为男性)均发生于行右肺切除术后(共11例肺切除术者)胺碘酮预防治疗组。认识到胺碘酮治疗的一些病人会出现严重并发症.遂决定回顾性地评定4年来本单位肺手术后ARDS的发生率。1987年1月至1991年9月,共施行肺叶切除术310例、右肺切除术
Atrial arrhythmia often occurs after thoracic surgery, and atrial fibrillation in patients after pneumonectomy indicates a poor prognosis. The mortality rate can reach 25%. To this end, the authors conducted a prospective randomized study of 100 patients undergoing pneumonectomy and 200 lobectomy to assess the role of amiodarone, verapamil, and placebo in the prophylactic treatment of atrial fibrillation. As 3 patients with lung resection after amiodarone treatment group patients with serious life-threatening side effects, and thus continue to stop the test. At this point, 64 patients have undergone lobectomy and 32 have undergone pneumonectomy. All 3 ARDS (both men) occurred in the amiodarone prophylaxis group after right pneumonectomy (11 pneumonectomies). Recognizing the serious complications of some patients treated with amiodarone, we decided to retrospectively assess the incidence of ARDS after lung surgery in our unit over the past four years. January 1987 to September 1991, a total of 310 cases of lobectomy, right lung resection