成人异染性脑白质营养不良(MLD)是常染色体隐性遗传缺陷引起的神经系统脱髓鞘疾病,其最初的临床表现可以类似于精神分裂症或痴呆。精神症状可较神经系统症状早数十年出现。活人中诊断为成人MLD者迄今不超过12例。MLD可通过芳基硫酸脂酶 Adult heteromonotic leukodystrophy (MLD) is a neurodegenerative demyelinating disease caused by autosomal recessive genetic defects, and its initial clinical manifestations may be similar to schizophrenia or dementia. Psychiatric symptoms can occur as early as decades of nervous system symptoms. To date, no more than 12 patients have been diagnosed with adult MLD. MLD can pass arylsulfatase