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目的探讨血小板高反应性对冠心病合并糖尿病患者行PCI术后发生临床终点事件的预测价值。方法回顾性分析行PCI的患者263例,平均随访(362.6±66.7)d。根据是否诊断为糖尿病,分为糖尿病组61例和非糖尿病组202例。二磷酸腺苷(ADP)诱导的血小板高反应性(HPR)定义为血小板聚集率≥50%。结果糖尿病组患者ADP诱导的HPR比例显著高于非糖尿病组(27.9%vs 16.3%,P=0.044)。糖尿病组HPR患者PCI术后主要不良心血管事件(MACE)发生率显著高于非HPR患者(35.3%vs 6.8%,P=0.016),HPR与PCI术后发生MACE的相关系数在糖尿病组与非糖尿病组中分别为0.361(P=0.01,95%CI:1.6~64.7)、0.277(P=0.209,95%CI:0.6~7.5)。结论 HPR与MACE的关系在糖尿病组要强于非糖尿病组。
Objective To investigate the predictive value of platelet hyperresponsiveness in patients with coronary heart disease complicated with diabetes after PCI. Methods A retrospective analysis of 263 cases of patients with PCI, the average follow-up (362.6 ± 66.7) d. According to whether the diagnosis of diabetes, divided into diabetes group 61 cases and non-diabetic group 202 cases. Adenosine diphosphate (ADP) -induced platelet hyperreactivity (HPR) was defined as platelet aggregation rate> 50%. Results ADR-induced HPR in diabetic patients was significantly higher than that in non-diabetic patients (27.9% vs 16.3%, P = 0.044). The incidence of major adverse cardiac events (MACE) after PCI in diabetic patients with HPR was significantly higher than that of non-HPR patients (35.3% vs 6.8%, P = 0.016). The correlation coefficient of MACE between HPR and PCI was significantly lower in patients with diabetes mellitus Diabetic patients had 0.361 (P = 0.01, 95% CI: 1.6-64.7) and 0.277 (P = 0.209, 95% CI: 0.6-7.5), respectively. Conclusion The relationship between HPR and MACE is stronger in the diabetic group than in the non-diabetic group.