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目的 :探讨PD患者PBL免疫功能的变化。方法 :通过直接免疫荧光标记法 ,应用流式细胞仪 ,测定 3 5例PD患者与 18名健康对照者CD3 + 、CD4+ 、CD8+ 淋巴细胞亚群百分比及淋巴细胞总百分比 ,计算CD4+ /CD8+ 的比值。结果 :PD患者CD4+ T细胞百发比和淋巴细胞总百分比降低 ,CD8+ T细胞的百分比不变 ,CD4+ /CD8+ 的比值较正常人显著降低 ,男性患者上述指标的下降更明显。多巴制剂的服用对淋巴细胞亚群的变化无影响。结论 :PD患者存在细胞免疫功能的异常。
Objective: To investigate the changes of PBL immune function in PD patients. Methods: The percentage of CD3 +, CD4 +, CD8 + lymphocyte subsets and percentage of lymphocytes in 35 PD patients and 18 healthy controls were determined by direct immunofluorescence labeling and flow cytometry, and the ratio of CD4 + / CD8 + . Results: The percentage of CD4 + T cells and percentage of CD8 + T cells in PD patients were decreased, but the percentage of CD4 + / CD8 + cells was significantly lower than that in normal subjects. The decline of these indexes was more obvious in male patients. Dopa preparations did not affect changes in lymphocyte subsets. Conclusion: PD patients have abnormal cellular immune function.