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目的:观察血清降钙素原(PCT)与新生儿感染性肺炎的相关性。方法:以我院接受治疗的45例感染性新生儿患儿为观察对象,同时选取50例健康新生儿作为对照组。观察两组患儿血清PCT水平、血清炎症细胞因子水平和血气指标的差异,分析PCT与炎症细胞因子水平和血气指标的相关性。结果:感染组PCT、IL-18、IL-6和hs-CRP水平分别为(6.24±2.08),(32.35±6.89),(18.68±5.24)和(12.28±3.16)μg/ml,明显高于对照组,差异具有统计学意义(P<0.05);感染组患儿SpO_2水平及P_(ET)CO_2水平均显著降低,而两组患者的血pH水平无明显差别(P>0.05);PCT与IL-18、IL-6和hs-CRP水平显著正相关(r=0.612,0.595和0.569,P<0.05),而与血pH、SpO_2和PETCO_2水平无明显相关关系。结论:感染性新生儿患儿血清PCT水平较高,且与患者的血清炎症细胞因子水平密切相关,可作为临床监测指标。
Objective: To observe the correlation between serum procalcitonin (PCT) and neonatal pneumonia. Methods: Forty-five infants with infectious neonates undergoing treatment in our hospital were selected as observation subjects, and 50 healthy newborns were selected as control group. The levels of serum PCT, serum levels of inflammatory cytokines and blood gas indexes in two groups were observed, and the correlation between PCT and inflammatory cytokines and blood gas indexes was analyzed. Results The levels of PCT, IL-18, IL-6 and hs-CRP in the infected group were significantly higher than those in the infected group (6.24 ± 2.08, 32.35 ± 6.89, 18.68 ± 5.24 and 12.28 ± 3.16 μg / ml, respectively (P <0.05). The levels of SpO_2 and P_ (ET) CO_2 in the infected group were significantly lower than those in the control group (P> 0.05) IL-18, IL-6 and hs-CRP levels were positively correlated (r = 0.612,0.595 and 0.569, P <0.05), but not with pH, SpO_2 and PETCO_2 levels. Conclusion: The serum PCT level in infants with infectious neonates is high, which is closely related to the level of serum inflammatory cytokines in patients and may be used as a clinical monitoring index.